Nat Commun. 2016 Jan 7;7:10147. doi: 10.1038/ncomms10147.
Lorenzi H1,
Khan A2,3,
Behnke MS2,4,
Namasivayam S5,6,
Swapna LS7,8,
Hadjithomas M1,
Karamycheva S1,
Pinney D9,
Brunk BP9,
Ajioka JW10,
Ajzenberg D11,
Boothroyd JC12,
Boyle JP13,
Dardé ML11,
Diaz-Miranda MA9,
Dubey JP14,
Fritz HM15,
Gennari SM16,
Gregory BD9,
Kim K17,
Saeij JP18,
Su C19,
White MW20,
Zhu XQ21,
Howe DK22,
Rosenthal BM14,
Grigg ME3,
Parkinson J7,8,
Liu L23,24,
Kissinger JC5,6,24,
Roos DS9,
David Sibley L2.
Abstract
Toxoplasma gondii is among the most prevalent parasites worldwide, infecting many wild and domestic animals and causing zoonotic infections in humans. T. gondii differs substantially in its broad distribution from closely related parasites that typically have narrow, specialized host ranges. To elucidate the genetic basis for these differences, we compared the genomes of 62 globally distributed T. gondii isolates to several closely related coccidian parasites. Our findings reveal that tandem amplification and diversification of secretory pathogenesis determinants is the primary feature that distinguishes the closely related genomes of these biologically diverse parasites. We further show that the unusual population structure of T. gondii is characterized by clade-specific inheritance of large conserved haploblocks that are significantly enriched in tandemly clustered secretory pathogenesis determinants. The shared inheritance of these conserved haploblocks, which show a different ancestry than the genome as a whole, may thus influence transmission, host range and pathogenicity.
- PMID:
- 26738725
- [PubMed - in process]
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