Thursday, January 07, 2016

Antigen Presentation of Vacuolated Apicomplexans - Two Gateways to a Vaccine Antigen

2015 Dec 27. pii: S1471-4922(15)00284-6. doi: 10.1016/j.pt.2015.12.011. [Epub ahead of print]
 
For parasites that sequester themselves within a vacuole, new rules governing antigen presentation are coming into focus. Components of the host's autophagy machinery and the parasite's membranous nanotubular network within the parasitophorous vacuole play a major role in determining antigenicity of Toxoplasma proteins. As such, both parasite and vaccinologist may exploit these pathways to regulate the ever important CD8 T cell response to apicomplexan parasites.
Copyright © 2015. Published by Elsevier Ltd.
PMID:
26733404
[PubMed - as supplied by publisher]
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1 comment:

Chloe said...

Hope the gateways could be effective in vaccine antigen. Since life sciences research has developed at a diversified direction, whether acetyl phenylalanine can be applied into antigen discovery?

12:43 AM

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