Wednesday, October 12, 2011

The role of melatonin in parasite biology

Mol Biochem Parasitol. 2011 Oct 1. [Epub ahead of print]

The role of melatonin in parasite biology

Bagnaresi P, Nakabashi M, Thomas AP, Reiter RJ, Garcia CR

SourceDepartamento de Biofísica, Universidade Federal de São Paulo, São Paulo, Brazil.

Abstract
Regarded as the circadian hormone in mammals, melatonin is a highly conserved molecule, present in nearly all species. In this review, we discuss the role of this indolamine and its precursors in the cell biology of parasites and the role of the molecule in the physiology of the host. In Plasmodium, melatonin can modulate intracellular concentrations of calcium and cAMP, which in turn can regulate kinase activity and cell cycle. In Trypanosoma infections, modulation of the immune system by melatonin is extremely important in controlling the parasite population. Melatonin also contributes to the inflammatory response to Toxoplasma gondii infection. Thus, there are a number of unique adaptations involving intricate connections between melatonin and the biology of the parasite-host relationship.

Copyright © 2011. Published by Elsevier B.V.

PMID:21982826[PubMed - as supplied by publisher]

10 comments:

Alvaro said...

This melatonin posting, completely useful..

Tanya Albert said...

Am Tanya Albert, Herpes wanted to destroy me, but with the help of Dr.Ekpiku i escaped the death that was on my way, i am here to testifies on how Dr Ekpiku help me to cure my sickness called Herpes which has been eating me up for 2 years and 4 months, i also saw online how he has cured so many people, Dr Ekpiku is a great herbalist that treats and cure all manner of diseases like Herpes, HIV, Cancer, Syphilis, Hepatitis B, all types of Cancer, Gonorrhea, and solves life's problems that you might have etc.. contact him today and he will help you solved your problem, contact him via ekpikuspelhomeofgrace@gmail.com or ekpikuspelhomeofgrace@hotmail.com call +2348073673757 OR whatsapp him. THESE ARE THE THINGS Dr. Ekpiku. HERPES. HIV/AIDS. CANCER.

Mabel Raymond said...



Im Mabel Raymond, Iam a USA citizen. You can also add me on Facebook by my name Mabel Raymond or send me an email Mabelraymond8400@gmail.com and i do not know why people are copying people's testimony for fake herbal Doctors and spell casters in Nigeria. And they will continue to share false and fake testimony. Trying to fraud innocent people of their money...
I am here to share a marvelous testimony, because i have being scam of $2,640USD by DR Odogu. Who so ever that claim such email is a scam. But i thank a kind Godsent man who cured my herpes. Dr. OSAS herbal medicine is a good remedy for Herpes. I was a carrier of Herpes and I saw a testimony on how Dr. OSAS cure Herpes, I decided to contact, I contacted him and he guided me. I asked him for solutions and he started the remedies for my health and sent the herbal medicine to me here in USA. Thank God, now everything is fine, I'm cured by Dr. OSAS herbal medicine, I'm very thankful to Dr. OSAS. Right now i can tell you that few months now i have not had any pain and outbreaks. And i have just went for test last week and the doctor confirmed that there is no trace of any herpes system in my body. Reach him on doctorosasherbalhome@gmail.com Or contact his number via +2348112252378 or you can as well add him on whatsapp with same number Or better still, you can call my cell phone number on +12702545418 or you can also reach me on my blog wall on http://mabelraymond.blogspot.com/ and you will be free and free forever, Try it and you will not regret it because it truly works. One thing i have come to realize. ((((FACT)))


DOCTOR OSAS CAN AS WELL CURE THE FOLLOWING DISEASE:-

1. HIV/AIDS
2. HERPES
3. CANCER ALL KINDS
4. ALS
5. Hepatitis A,B,C
6. Diabetes
7. CHRONIC DISEASE
8. Coronary Artery Disease (Ischemic Heart Disease)

Brittany Doggies said...

Appreciation is the key to doing more that is why I have took some time out to thank some one who cured me of my 2 years Herpes Simplex problem. It became a major problem to me as it was affecting my marital life and I was no longer comfortable so I decided to look for a solution and I came across a post of Dr Lusanda and how he has been helping people of the same problem I contacted him and told him all I have been facing in my life. He told me how to get his product and how to take it after every thing I find out that all was now okay with me and that my Herpes problem was gone that is why I have come out today to say thank you to him and for any problem either from man or woman. Contact him on Drlusandaherbal@gmail.com or website on www.drlusandaherbals.weebly.com

Alle Amber said...

ATTENTION YOU ALL. i wish to inform you all

that after all the herbal doctor that i contacted, Dr Monday (nativeherbalclinic@gmail.com) was the

only one that cured my Herpes Virus with his Herbal Medicine.

i have contacted about 4 different herbal doctor and i was just been SUCKED. well thats the past.

Am very happy now that am cured finally by Dr Monday.

I contacted

Dr Monday just last week when i was confused on who to contact, and he

gave me an online Details center to fill. i filled the form with my

details and he wrote back to me that it will take (3 Weeks) for

me to get cure. To my greatest surprise, after two weeks i

go for a medical check up to confirm my STATUS. and i went to 6

different hospital and i was tested NEGATIVE. so i decided to inform the

general public so that you wont waste time sharing tears and losing

hope.

you can email him Dr Monday on his email: nativeherbalclinic@gmail.com

or visit Www.nativeherbalclinic.webs.com

PLEASE contact to avoid disappointment

Vilma Braga said...

Meu nome é (Vilma Braga), sou muito grato compartilhar esses ótimos testemunhos com você. A melhor coisa que já aconteceu na minha vida é como eu consegui sobreviver à hepatite
B. Eu sou uma mulher que acredita que nunca consigo curar minha doença, mas uma amiga me deu um contato desse homem chamado Dr. Oseamuyi, o que eu fiz. Finalmente, meus sonhos surgiram quando eu envio o E-mail ao Dr. Oseamuyi. E diga-lhe que estou cansado de câncer, ele me pede para não se preocupar com isso, ele me curará. Entretanto, foi uma piada, mas depois que o elenco é mágico para mim, fiquei curado, mas não foi tão fácil para mim até o dia em que conheci o feitiço online que tantas pessoas falaram sobre o fato de ele ser muito bom em lançar Todo tipo de doença, então eu decido tentar. Eu entrei em contato com este homem e ele me fez um feitiço e me envia um item que eu levo, mas acredite em mim quando eu uso essas coisas que ele me deu. E minha vida ficou melhor ...... então, se você quiser ajuda, entre em contato com ele agora, https://professoroseamuyi.wixsite.com/herbal-centre ou você pode contatá-lo agora por telefone: +2348077544690 é aquele endereço de e-mail, Obrigado a todos e por aqueles que entrarão em contato com ele será livre, assim como eu estiver no nome de Jesus, amen.

Jessica Ana said...

Am here to appreciate Dr Aba for using his herbal medicine to cure my Herpes virus. since 3 years now I have been living with this virus and it has been giving me challenges, I was so perplexed cause i have been taking several drugs to be cured but all of my effort was in vain,one morning i was browsing through the internet then i saw several testimonies about Dr. Aba curing people from Herpes virus and immediately i contacted Dr. Aba on his email: dr.abaherbalhome@gmail.com, i told him about my troubles and he told me that i must be cured, gave me some instructions and which i rightly followed. so he prepared a herbal medicine for me and sent it to me which i used for 2 weeks and everything was like a dream to me and my Herpes virus was totally gone, why don't you contact him today and be free from your diseases because he is very good and honest Doctor. contact him via email; dr.abaherbalhome@gmail.com or whatsApp him on +2348107155060

Wilson Care said...

Thanks to dr.ezomo for his good work I never believe that HIV has cure, I
was HIV positive over 3 year now before I came across a comment about how
dr.ezomo cure HIV and herpes disease but when I saw it i have it in mind
that he can’t cure HIV I just decided to give it a try I contact him that
night luckily to me he replied me, but I don’t believe him I thought it was
a scam but I still hold on to see the work of Dr ezomo if he is saying the
truth he ask for some details about me i gave him all he needed and I
waited to see his reply to my problem after all, he told me to go for check
up and I went for HIV test I cant believe I was negative,am so happy and
grateful to God for using Dr ezomo to cure me, that is the reason why i
decided to write this wonderful testimony of our i was cured, i recommend
Dr ezomo to you all around the world,contact him on his Email dr.ezomorootandherbals@gmail.com or you can also reach him through thanks
dr.ezomo for helping me at this young age if you need help contact,
He can also cure so many sickness
{1}HIV And AIDS
{2}Diabetes
{3}Epilepsy
{4} Blood Cancer
{5} HPV
{7} ALS
{8} Hepatitis
{9}Love Spell

Lace Bern said...

Do anyone still doubt natural herbs? Now i can boldly say that I've seen the great importance of natural herbs and the wonderful work the nautrual herbs have done in my life and that of peoples. Some time I wonder why people still spend their money on surgery, injections and drugs each time they are sick and yet they don't get cured but with natural herbs you will be cured permanently. Natural herbs can cure all kinds of illness including herpes, diabetics, asthma, HIV, hepatitis, etc. I've seen it with my own eyes. I was cured of Herpes and my aunt and her husband were cured of HIV by Dr. Tokubo who uses natural herbs to cure different kind of illness. Even Dr. Sebi prove to the whole world that natural herbs can cure all diseases and he cured countless of people using natural herbs. I know is hard to believe but am a living testimony. There is no harm in trying herbs.Contact or email Dr. tokubo on: DRTOKUBOTEMPLE@GMAIL.COM (phone/whatsap no): +2349037990322

tracy evans said...

attention you all,i don't just know the reason why some people is finding it difficult to believe that there is a cure for HIV, i have been HIV+ since last three years with my boyfriend but today i am happy that i am HIV_ with herbal medicine of Dr.Emmanuel the great healer,i was browsing the Internet searching for help when i came across a testimony shared by someone on how Dr.Emmanuel cure his HIV i was so much in need of getting his treatment but after all Dr.Emmanuel brought a smile to my face with his herbal medicine. i am so much happy today that we have someone like this great healer out there, so my people out there kindly contact this great healer on his email address: Traditionalherbalhealingcentre@gmail.com please sir keep your good work cause there are people out there who is in need of your healing medicine.once more contact him now: traditionalherbalhealingcentre@gmail.com or WhatsApp/call him at +2348140033827 once you get inturch with him tell him that i Tracy inform you about is ambition work.good lucky....