Thursday, December 14, 2006

Toxo infection and neuromental disorders

Clin Dev Immunol. 2006 Jun-Dec;13(2):167-83.

The possible role of transplacentally-acquired antibodies to infectious agents, with molecular mimicry to nervous system sialic acid epitopes, as causes of neuromental disorders: Prevention and vaccine implications.

Nahmias AJ, Nahmias SB, Danielsson D.

Pediatric Infectious Diseases, Epidemiology and Immunology Division, Department of Pediatrics and School of Public Health (emeritus), Emory University, Atlanta, GA, 30322, USA.

Proof of causality of most neuromental disorders (NMD's) is largely unavailable. Lessons from four-decade investigations of the epidemiology, immunology, pathogenesis, prevention and therapy of perinatal infectious agents, which invade directly the nervous system, have led us to propose a new indirect effect hypothesis: maternal transplacentally-acquired antibodies, to agents with epitope molecular mimicry with the developing nervous system, can cross the fetus/infant's blood-nervous system barriers to cause NMD's, clinically manifest years later.Further rationale is provided by relevant evolutionary/developmental (EVO-DEVO) considerations-applicable also to some vaccines. The hypothesis is being tested in: (a) older pregnancy studies with available maternal and newborn sera, and follow-up of the progeny for NMD's; and (b) NMD registry individuals linked to their stored newborn blood spots. Preliminary results support a possible role for schizophrenia of high-tittered antibodies to some agents (toxoplasma, influenza and herpes simplex type 2 virus).A model that includes likely genetic and postnatal influences is schematized and a list of putative agents and factors, based on varying rationales, is tabulated. In case pilot studies are confirmed, the identified agent(s) and antibodies would need to be tested in new prospectively enrolled pregnant women, so as to establish further risk factors leading to possible preventive modalities.

1 comment:

Lisa Mcclean said...

100% percent sure! The only person that i can boldly say he can cure GENITAL HERPES VIRUS and any other kind of disease like CANCER,HIV/AIDS,LOW SPERM COUNT,MENOPAUSE DISEASE,ASEPSIS and can also solve any relationship problem, is this great herbalist man called DR.OKOJIE after i came in contact with him, thank you DR.OKOJIE for restoring my relationship back and CURE GENITAL HERPES out of my body. You can contact him via email: or call or whatsapp 2347067358924 or my email