Thursday, December 14, 2006

Toxo in astrocytes: IL-12 and -10

J Parasitol. 2006 Oct;92(5):1108-10.

Toxoplasma gondii in human astrocytes in vitro: interleukin (IL)-12 and IL-10 do not influence cystogenesis

Estran C, Brenier-Pinchart MP, Pelletier L, Cesbron-Delauw MF, Pelloux H.

Laboratoire Adaptation et Pathogenie des Microorganismes, UMR 5163 CNRS-UJF, Universite J. Fourier, Campus Sante, Grenoble, France.

Interleukin (IL)-12, IL-10, and interferon (IFN)-gamma are major cytokines involved in the immune response against Toxoplasma gondii. Nevertheless, the role of IL-12 and IL-10 in the control of parasite replication and cytogenesis is not known yet, whereas the importance of IFN-gamma is documented. Furthermore, it is of paramount importance to study the interaction between T. gondii and cells from the central nervous system, e.g., astrocytes. In this study, we report that IL-12 and IL-10 have no effect on penetration, replication, or cystogenesis of the T. gondii Prugniaud strain in human astrocytes in vitro and do not antagonize the role of IFN-gamma on cystogenesis.

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