Research advances in interactions related to Toxoplasma gondii microneme proteins

Exp Parasitol. 2017 Mar 9. pii: S0014-4894(16)30389-7. doi: 10.1016/j.exppara.2017.03.001. [Epub ahead of print]

Liu Q¹, Li FC², Zhou CX³, Zhu XQ⁴.

Toxoplasma gondii microneme proteins (TgMICs), secreted by micronemes upon contact with host cells, are reported to play important roles in multiple stages of the T. gondii life cycle, including parasite motility, invasion, intracellular survival, and egress from host cells. Meanwhile, during these processes, TgMICs participate in many protein-protein and protein-carbohydrate interactions, such as undergoing proteolytic maturation, binding to aldolase, engaging the host cell receptors and forming the moving junction (MJ), relying on different types of ectodomains, transmembrane (TM) domains and cytoplasmic domains (CDs). In this review, we summarize the research advances in protein-protein and protein-carbohydrate interactions related to TgMICs, and their intimate associations with corresponding biological processes during T. gondii infection, which will contribute to an improved understanding of the molecular pathogenesis of T. gondii infection, and provide a basis for developing effective control strategies against T. gondii.

Copyright © 2017. Published by Elsevier Inc.

KEYWORDS:

Host cells; Microneme proteins; Protein-carbohydrate interactions; Protein-protein interactions; Toxoplasma gondii

PMID:

28286325

DOI:

10.1016/j.exppara.2017.03.001