iTRAQ-based differential proteomic analysis in Mongolian gerbil brains chronically infected with Toxoplasma gondii

J Proteomics. 2017 Mar 17. pii: S1874-3919(17)30096-9. doi: 10.1016/j.jprot.2017.03.012. [Epub ahead of print]

Lv L1, Wang Y1, Feng W1, Hernandez JA2, Huang W1, Zheng Y1, Zhou X1, Lv S1, Chen Y1, Yuan ZG3.

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BIOLOGICAL SIGNIFICANCE: 

T.gondii can infect almost all nucleated cells with a preference for the CNS, which can induce Toxoplasma encephalitis (TE). However, the pathogenesis and mechanisms between the parasite and host associated with TE are largely unexplored. Around 30% of the world population is considered to have latent infection with T.gondii and >90% patients died of TE, while the proportion of secondary paralysis is also high. Patients of TE may have highly varied neurological symptoms with both focal and diffuse neurological lesions, while mental symptoms and behavior disorders are frequently accompanied, like the Alzheimer's disease (AD). We present a comparative proteomics analysis to explore the differences of protein expression caused by chronic T.gondii infection. The results of this analysis can be helpful for identifying key proteins involved in the pathogenesis of TE. In addition, the study can contribute to a better understanding of molecular mechanisms underlying the host-parasite relationship in chronic infection of T.gondii and facilitate further development of new therapies for TE.

Copyright © 2017. Published by Elsevier B.V.

KEYWORDS: 

Mongolian gerbil; Neuroinfections; T.Gondii; Toxoplasma encephalitis; iTRAQ labeling

PMID:

 

28323244

 

DOI:

 

10.1016/j.jprot.2017.03.012