Pathog Dis. 2016 Nov 2. pii: ftw108. [Epub ahead of print]
Abstract
The obligate intracellular protozoan parasite Toxoplasma gondii actively invades virtually all warm-blooded nucleated cells. This process results in a non-fusogenic vacuole, inside which the parasites replicate continuously until egress signaling is triggered. In this work, we investigated the role of the large GTPase dynamin in the interaction of T. gondii with the host cell by using laser and electron microscopy during three key stages: invasion, development and egress. The detection of dynamin during invasion indicates the occurrence of endocytosis, while T. gondii egress appeared to be independent of dynamin participation. However, the presence of dynamin during T. gondii development suggests that this molecule plays undescribed roles in the tachyzoite's cell cycle.
© FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
- [PubMed - as supplied by publisher]
No comments:
Post a Comment