Saturday, August 22, 2015

Synthesis of the cyanobacterial metabolite nostodione A, structural studies and potent antiparasitic activity against Toxoplasma gondii

 2015 Aug 20. [Epub ahead of print]

McNulty J1, Keskar K, Jenkins HA, Werstiuk NH, Bordón C, Yolken R, Jones-Brando L.

Abstract

A total synthesis of the cyanobacterial natural product nostodione A is reported involving a convergent, diversity-oriented route, enabling the assembly of a mini-library of structural analogues. The first single crystal X-ray structural determination on a member of this series is reported along with SAR studies identifying potent inhibitors of invasion and replication of the parasitic protozoan Toxoplasma gondii.
PMID:
 
26291306
 
[PubMed - as supplied by publisher]
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1 comment:

Unknown said...

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7:10 AM

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