Nitric Oxide Production Increases During Toxoplasma gondii Encephalitis in Mice

Exp Parasitol. 2015 Jun 23. pii: S0014-4894(15)00169-1. doi: 10.1016/j.exppara.2015.06.009. [Epub ahead of print]

 

Dincel GC¹, Atmaca HT².

Abstract

Toxoplasma gondii is a intracellular parasite with the potential of causing severe encephalitis among immunocompromised human and animals. The aim of this experimental study was to investigate the immunomodulatory and immunopathological role of nitric oxide (NO) in central nervous systems and to identify any correlation between toxoplasmosis neuropathology and investigate the consequences of the cellular responses protect against Toxoplasma gondii. Mice were infected with ME49 strain Toxoplasma gondii and levels of endothelial, neuronal and inducible nitric oxide synthase (eNOS, nNOS, iNOS), glial fibrillary acidic protein (GFAP) and neurofilament (NF) were examined in brain tissues by immunohistochemistry, during the development and establishment of a chronic infection at 10 30 and 60 days post infection.

KEYWORDS:

Toxoplasma gondii; glial fibrillary acidic protein; neurofilament; neuropathology; nitric oxide

PMID:

26115941

[PubMed - as supplied by publisher]