Genotype-associated Arginase 1 Expression in Rat Peritoneal Macrophages induced by Toxoplasma gondii

J Parasitol. 2015 Apr 14. [Epub ahead of print]

 

Zhang Q¹, Kong L, Zhang Y, Chen H, An R, Wang W, Xu X, Zhang A, Cai Y, Li M, Wen H, Luo Q, Shen J, He L.

 

Toxoplasma gondii induces polarization of mouse macrophages, including both classically activated macrophage (M1) and alternatively activated macrophage (M2) in a genotype-related manner. Here we presented a novel result that the Wh6 strain with type Chinese 1, which is predominantly prevalent in China, induced Arg1 expression in a STAT6 dependent manner in primary rat peritoneal macrophages, compared to the PRU stain with typeⅡ that elicited a high expression of Arg1 in a C/EBPβ dependent manner. Additional experiment revealed that dexamethasone inhibited Arg1 expression in rat macrophage in both contexts. Our data suggested that Arg1 expression, which is abundant in polarized M2 cells, is associated with strain/genotype difference in varying pathways.

PMID:

25872571

[PubMed - as supplied by publisher]