Thursday, January 22, 2015

Toxoplasma secretory granules: one population or more?

 2015 Jan 15. pii: S1471-4922(14)00205-0. doi: 10.1016/j.pt.2014.12.002. [Epub ahead of print]

Mercier C1, Cesbron-Delauw MF2.

Abstract

In Toxoplasma gondii, dense granules are known as the storage secretory organelles of the so-called GRA proteins (for dense granule proteins), which are destined to the parasitophorous vacuole (PV) and the PV-derived cyst wall. Recently, newly annotated GRA proteins targeted to the host cell nucleus have enlarged this view. Here we provide an update on the latest developments on the Toxoplasma secreted proteins, which to date have been mainly studied at both the tachyzoite and bradyzoite stages, and we point out that recent discoveries could open the issue of a possible, yet uncharacterized, distinct secretory pathway in Toxoplasma.
Copyright © 2014 Elsevier Ltd. All rights reserved.

KEYWORDS: 

GRA proteins; Toxoplasma gondii; dense granules; protozoa
PMID:
 
25599584
 
[PubMed - as supplied by publisher]
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