Infect Immun. 2014 May 27. pii: IAI.01722-14. [Epub ahead of print]

Complex immune cell interplay in the IFN-γ response during Toxoplasma gondii infection

Sturge CR¹, Yarovinsky F².

Abstract

Toxoplasma gondii is an obligate intracellular parasite of clinical importance, especially in immunocompromised patients. Investigations into the immune response to the parasite found that T cells are the primary effector cells regulating IFN-γ-mediated host resistance. However, recent studies have revealed a critical role for the innate immune system in mediating host defense independently of the T cell responses to the parasite. This body of knowledge is put into perspective by the unifying theme that immunity to the protozoan parasite requires a strong IFN-γ host response. In the following review, we discuss the role of IFN-γ-producing cells and the signals that regulate IFN-γ production during T. gondii infection.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

PMID:

24866795

[PubMed - as supplied by publisher]