Wednesday, July 31, 2013

Key molecular events during host cell invasion by Apicomplexan pathogens

2013 Jul 26. pii: S1369-5274(13)00092-1. doi: 10.1016/j.mib.2013.07.004. [Epub ahead of print]

Key molecular events during host cell invasion by Apicomplexan pathogens

Sharma P, Chitnis CE.

Source

National Institute of Immunology (NII), New Delhi, India. Electronic address: pushkar@nii.ac.in.

Abstract

The ability of Apicomplexan parasites to invade host cells is key to their survival and pathogenesis. Plasmodium and Toxoplasma parasites share common mechanisms for invasion of host cells. Secretion of microneme and rhoptry proteins, tight junction formation and assembly of an acto-myosin motor are key steps for successful invasion by both parasites. Here, we review our understanding of the molecular basis for these steps.
Copyright © 2013 Elsevier Ltd. All rights reserved.
PMID:
23895827
[PubMed - as supplied by publisher]
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