Does protein phosphorylation govern host cell entry and egress by the Apicomplexa?

Int J Med Microbiol. 2012 Aug 27. [Epub ahead of print]

Does protein phosphorylation govern host cell entry and egress by the Apicomplexa?

Jacot D, Soldati-Favre D.

Department of Microbiology and Molecular Medicine, Faculty of Medicine, CMU, 1 Rue Michel-Servet, 1211 Geneva, Switzerland.

Members of the phylum Apicomplexa are responsible for a wide range of diseases in humans and animals. The absence of an effective vaccine or safe curing drugs and the continuous emergence of resistant parasites to available treatments impose a high demand on the identification of novel targets for intervention against the apicomplexans. Protein kinases are considered attractive potential therapeutic targets not only against cancers but also to combat infectious diseases. The scope and aim of this review is to report on the recent progress in dissecting the impact of protein phosphorylation in regulating motility and invasion.

PMID: 22951234 [PubMed - as supplied by publisher]