Review of the series "disease of the year 2011: toxoplasmosis" pathophysiology of toxoplasmosis

Ocul Immunol Inflamm. 2011 Oct;19(5):297-306

Review of the series "disease of the year 2011: toxoplasmosis" pathophysiology of toxoplasmosis

Subauste CS, Ajzenberg D, Kijlstra A.
SourceDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine , Cleveland, Ohio , USA ; Department of Ophthalmology and Visual Sciences, Case Western Reserve University School of Medicine , Cleveland, Ohio , USA ; and Department of Pathology, Case Western Reserve University School of Medicine , Cleveland, Ohio , USA.

Abstract
Toxoplasma gondii is a major cause of chronic parasitic infection in the world. This protozoan can cause retino-choroiditis in newborns and in adults, both immunocompetent and immunodeficient. This disease tends to be recurrent and can lead to severe visual impairment. The authors review current knowledge on the role of parasite genetics in influencing susceptibility to ocular toxoplasmosis and on the immuno-pathogenesis of this disease.

PMID:21970661[PubMed - in process]