Immunobiology. 2011 Aug 12. [Epub ahead of print]
Glycosylphosphatidylinositols of Toxoplasma gondii induce matrix metalloproteinase-9 production and degradation of galectin-3
Niehus S, Elass E, Coddeville B, Guérardel Y, Schwarz RT, Debierre-Grockiego F
SourceInstitut für Virologie, AG Parasitologie, Philipps-Universität, Marburg, Germany; UPR9022 du CNRS, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, 67084 Strasbourg, France.
Abstract
Toxoplasma gondii glycosylphosphatidylinositols (GPIs) bind to galectin-3 to induce TNF-α production in macrophages via Toll-like receptors 2 and 4. Here we show that T. gondii GPIs stimulate human macrophages to synthesize matrix metalloproteinase-9 in a TNF-α-dependent pathway and degrade extracellular galectin-3.
Copyright © 2011 Elsevier GmbH. All rights reserved.
PMID:21924517[PubMed - as supplied by publisher]
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