Toxoplasma gondii infection and abdominal hernia: evidence of a new association

Parasit Vectors. 2011 Jun 17;4(1):112. [Epub ahead of print]

Toxoplasma gondii infection and abdominal hernia: evidence of a new association

Alvarado-Esquivel C, Estrada-Martinez S.
Abstract
ABSTRACT:

BACKGROUND: We performed a retrospective, observational study in 1156 adult subjects from the general population of Durango City, Mexico, Fifty five subjects with a history of abdominal hernia repair and 1101 subjects without hernia were examined with enzyme-linked immunoassays for the presence of anti-Toxoplasma IgG and IgM antibodies.

RESULTS: The seroprevalence of anti-Toxoplasma IgG antibodies and IgG titers was significantly higher in subjects with abdominal hernia repair than those without hernia. There was a tendency for subjects with hernia repair to have a higher seroprevalence of anti-Toxoplasma IgM antibodies than subjects without hernia. The seroprevalence of anti-Toxoplasma IgG antibodies in subjects with hernia repair was significantly higher in subjects [greater than or equal to]50 years old than those <50 years old. Further analysis in subjects aged [greater than or equal to]50 years showed that the seroprevalence of anti-Toxoplasma IgG antibodies was also significantly higher in individuals with hernia repair than those without hernia (OR = 2.72; 95% CI: 1.10-6.57). Matching by age and sex further showed that the seroprevalence of Toxoplasma infection was significantly higher in patients with hernia repair than those without hernia (OR: 4.50; 95% CI: 1.22-17.33).

CONCLUSIONS: Results indicate that infection with Toxoplasma is associated with abdominal hernia. The contributing role of infection with Toxoplasma in abdominal hernia was observed mainly in subjects aged [greater than or equal to]50 years old. Our results might have clinical, prevention and treatment implications and warrant for further investigation.

PMID:21682896[PubMed - as supplied by publisher]