J Parasitol. 2010 Feb 26:1. [Epub ahead of print]
In vitro differential phenotypic characteristics among type II Toxoplasma gondii strains from congenital toxoplasmosis in humans
Brenier-Pinchart MP, Bertini RL, Maubon D, Pelloux H.
Abstract
In France, more than 80% of human congenital toxoplasmosis is attributable to Toxoplasma strains belonging to type II lineage, while three main lineages have been described in Europe. Cell invasion, parasite replication and cyst formation of type II strains isolated from congenital infections were compared in a human cell model. The phenotype patterns of the four type II strains studied differed from each other: the two strains responsible for asymptomatic infection formed significantly fewer cysts than the two strains isolated from symptomatic toxoplasmosis. The capacity to form cysts was different among the type II strains studied and may be related to the clinical form.
PMID: 20476804 [PubMed - as supplied by publisher]
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