Deploying parasite profilin on a mission of invasion and danger

Cell Host Microbe. 2008 Feb 14;3(2):61-3.

Deploying parasite profilin on a mission of invasion and danger

Denkers EY, Striepen B

Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. eyd1@cornell.edu

Interleukin-12 (IL-12) is important in inducing Th1 responses during infection with microbial pathogens such as the protozoan Toxoplasma gondii. In this issue of Cell Host & Microbe, Plattner and colleagues describe an engineered Toxoplasma strain that lacks profilin, an actin-binding molecule previously implicated in Toll-like receptor-11-dependent IL-12 induction and now shown to be important in parasite motility and host cell invasion.

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PMID: 18312839 [PubMed - in process]