Tuesday, October 11, 2016

Impaired health status and increased incidence of diseases in Toxoplasma-seropositive subjects - an explorative cross-sectional study

2016 Oct 10:1-16. [Epub ahead of print]

The global seroprevalence of latent toxoplasmosis is estimated to be higher than 30%. The presence of slowly dividing parasites in tissue cysts located mainly in immunoprivileged organs was long considered asymptomatic. Recently, many studies have shown that latent Toxoplasma infections could have serious impacts on human health. Here we ran a cross-sectional study in a population of 1486 volunteers. The results showed that 333 infected subjects scored worse than 1153 controls in 28 of 29 health-related variables. Similarly, they reported higher rates of 77 of a list of 134 disorders reported by at least 10 participants of the study. Toxoplasmosis was associated most strongly with musculoskeletal (τ = 0·107, P < 0·0005), followed by neurological (τ = 0·088, P < 0·0005), immune (τ = 0·085, p < 0·0005), metabolic (τ = 0·079, P < 0·0005), respiratory (τ = 0·068, P = 0·0001), allergic (τ = 0·053, P = 0·004), digestive system (τ = 0·052, P = 0·004) and mental health disorders (τ = 0·050, P = 0·008). Results of the present cohort study, along with the previous data from many case-control studies or ecological studies suggest that latent toxoplasmosis represents a large and so far underrated public health problem.


Toxoplasma gondii ; Parasite; disease burden; neglected disease; neglected zoonosis; public health; toxoplasmosis
[PubMed - as supplied by publisher]

1 comment:

albina N muro said...

Public health study in its generality covers two broader areas: Epidemiology and Clinical Trials. Epidemiology is a systematic study of using observational data collected from a study population that are not under the influence of experimental settings to learn about disease cause and origin (ethology) Diseases.