Wednesday, October 07, 2015

p62 Plays a Specific Role in Interferon-γ-Induced Presentation of a Toxoplasma Vacuolar Antigen

2015 Sep 30. pii: S2211-1247(15)01016-5. doi: 10.1016/j.celrep.2015.09.005. [Epub ahead of print]
 
 
Also known as Sqstm1, p62 is a selective autophagy adaptor with a ubiquitin-binding domain. However, the role of p62 in the host defense against Toxoplasma gondii infection is unclear. Here, we show that interferon γ (IFN-γ) stimulates ubiquitin and p62 recruitment to T. gondii parasitophorous vacuoles (PVs). Some essential autophagy-related proteins, but not all, are required for this recruitment. Regardless of normal IFN-γ-induced T. gondii clearance activity and ubiquitination, p62 deficiency in antigen-presenting cells (APCs) and mice diminishes the robust IFN-γ-primed activation of CD8+ T cells that recognize the T. gondii-derived antigen secreted into PVs. Because the expression of Atg3 and Irgm1/m3 in APCs is essential for PV disruption, ubiquitin and p62 recruitment, and vacuolar-antigen-specific CD8+ T cell activation, IFN-γ-mediated ubiquitination and the subsequent recruitment of p62 to T. gondii are specifically required for the acquired immune response after PV disruption by IFN-γ-inducible GTPases.
Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.
PMID:
26440898
[PubMed - as supplied by publisher]

1 comment:

Venus Timberlake said...

P62 will stimulate the immune response of body in the presentation of a Toxoplasma vacuolar antigen. Hope that more direct presentation would be displayed to explain how it work.