Sunday, June 28, 2015

Comparative Analysis of Apicoplast-Targeted Protein Extension Lengths in Apicomplexan Parasites

 2015;2015:452958. doi: 10.1155/2015/452958. Epub 2015 May 31.


In general, the mechanism of protein translocation through the apicoplast membrane requires a specific extension of a functionally important region of the apicoplast-targeted proteins. The corresponding signal peptides were detected in many apicomplexans but not in the majority of apicoplast-targeted proteins in Toxoplasma gondii. In T. gondii signal peptides are either much diverged or their extension region is processed, which in either case makes the situation different from other studied apicomplexans. We propose a statistic method to compare extensions of the functionally important regions of apicoplast-targeted proteins. More specifically, we provide a comparison of extension lengths of orthologous apicoplast-targeted proteins in apicomplexan parasites. We focus on results obtained for the model species T. gondii, Neospora caninum, and Plasmodium falciparum. With our method, cross species comparisons demonstrate that, in average, apicoplast-targeted protein extensions in T. gondii are 1.5-fold longer than in N. caninum and 2-fold longer than in P. falciparum. Extensions in P. falciparum less than 87 residues in size are longer than the corresponding extensions in N. caninum and, reversely, are shorter if they exceed 88 residues. 
[PubMed - in process]

1 comment:

JumpinJoe said...

Iron plays an important role in Toxo replication via glycoprotein and aquiring cholesterol I am putting this out there I believe that Plantar Fibromas in the foot could be toxoplasmosis and needs to be investigated Inner ear infections are misdiagnosed and could be toxoplasmosis Physicians do not have enough knowledge on this subject