Friday, November 21, 2014

Dynamic two-photon imaging of the immune response to Toxoplasma gondii infection

 2014 Nov 19. doi: 10.1111/pim.12161. [Epub ahead of print]


Toxoplasma gondii is a highly successful parasite that can manipulate host immune responses to optimise its persistence and spread. As a result, a highly complex relationship exists between T. gondii and the immune system of the host. Advances in imaging techniques, and in particular, the application of two-photon microscopy to mouse infection models, has made it possible to directly visualize interactions between parasites and the host immune system as they occur in living tissues. Here we will discuss how dynamic imaging techniques have provided unexpected new insight into (1) how immune responses are dynamically regulated by cells and structures in the local tissue environment, (2) how protective responses to T. gondii are generated, and (3) how the parasite exploits the immune system for its own benefit. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.


Toxoplasma gondii ; CD169; Collagen; Macrophage; NK cell; T cell; brain; dendritic cell; dynamic imaging; intestine; lymph node; microscopy; motility; two-photon
[PubMed - as supplied by publisher]

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