Wednesday, August 20, 2014

One minute ultraviolet exposure inhibits Toxoplasma gondii tachyzoite replication and cyst conversion without diminishing host humoral-mediated immune response

2014 Aug 14. pii: S0014-4894(14)00191-X. doi: 10.1016/j.exppara.2014.08.001. [Epub ahead of print
We developed a protocol to inactivate Toxoplasma gondii (T. gondii) tachyzoites employing 1 minute of ultraviolet (UV) exposure. We show that this treatment completely inhibited parasite replication and cyst formation in vitro and in vivo but did not affect the induction of a robust IgG response in mice. We propose that our protocol can be used to study the contribution of the humoral immune response to rodent behavioral alterations following T. gondii infection.
Copyright © 2014. Published by Elsevier Inc.


Animal models; Behavior; Immune response; Inactivation, Cysts; Toxoplasma
[PubMed - as supplied by publisher]

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