Antimicrob Agents Chemother. 2013 Aug 26. [Epub ahead of print]
In vitro effects of novel ruthenium complexes in Neospora caninum and Toxoplasma gondii tachyzoites
SourceInstitute of Parasitology, Vetsuisse Faculty, University of Berne, Länggass-Strasse 122, CH-3012 Berne, Switzerland.
Upon screening of 16 anti-proliferative compounds against Toxoplasma gondii and Neospora caninum, two hydrolytically stable ruthenium complexes (16, 18) exhibited IC50 values of 18.7 and 41.1 nM (T.gondii) and 6.7 and 11.3nM (N.caninum). To achieve parasiticidal activity for compound 16, long-term treatments (22-27 days at 80-160nM) were required. TEM demonstrated the rapid impact and ultrastructural alterations in both parasites. The potential of ruthenium-based compounds should thus be further exploited.
- [PubMed - as supplied by publisher]