Hum Vaccin Immunother. 2012 Sep 1;8(9). [Epub ahead of print]
Vaccines against Toxoplasma gondii: Status, challenges and future direction
Liu Q, Singla L, Zhou H.
Department of Parasitology, Shandong University School of Medicine; Jinan, Shandong, China.
Toxoplasma gondii is a ubiquitous protozoan parasite that can infect a wide range of animals including humans. This single known species in the genus Toxoplasma is considered as one of the most successful eukaryotic pathogens in terms of the number of host species and percentage of animals infected worldwide. Effective vaccines may contribute toward preventing and controlling the spread of toxoplasmosis. The present communication addresses the current status of development of vaccines against T. gondii. Further discussion is made on the difficulties along with challenges, such as vaccine construct, mode of vaccine administration and standardization of immunization evaluation. Finally suggestions are made on possible directions for future research for development of vaccines against T. gondii.
PMID: 22906945 [PubMed - as supplied by publisher]