Immunity. 2012 Aug 24;37(2):191-3.
Guanylate-binding proteins: niche recruiters for antimicrobial effectors
Dupont CD, Hunter CA.
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 380 South University Avenue, Philadelphia, PA 19104, USA.
There are fundamental questions regarding how IFN-γ activates host cells to eliminate intracellular pathogens. In this issue of Immunity, Yamamoto et al. (2012) demonstrate a critical role for the p65 guanylate-binding proteins (GBPs) in this process during infection with Toxoplasma gondii.
PMID: 22921115 [PubMed - in process]