Parasitol Int. 2011 Dec 24. [Epub ahead of print]
Roles of Apicomplexan protein kinases at each life cycle stage.
Kato K, Sugi T, Iwanaga T.
Inhibitors of cellular protein kinases have been reported to inhibit the development of Apicomplexan parasites, suggesting that the functions of protozoan protein kinases are critical for their life cycle. However, the specific roles of these protein kinases cannot be determined using only these inhibitors without molecular analysis, including gene disruption. In this report, we describe the functions of Apicomplexan protein kinases in each parasite life stage and the potential of pre-existing protein kinase inhibitors as Apicomplexan drugs against, mainly, Plasmodium and Toxoplasma.
Copyright © 2011. Published by Elsevier Ireland Ltd.
PMID: 22209882 [PubMed - as supplied by publisher]