Trends Parasitol. 2011 Nov 11. [Epub ahead of print]
The placenta: a main role in congenital toxoplasmosis?
Robert-Gangneux F, Murat JB, Fricker-Hidalgo H, Brenier-Pinchart MP, Gangneux JP, Pelloux H.
SourceLaboratoire de Parasitologie-Mycologie, Centre Hospitalier et Universitaire de Rennes, Rennes, France; EA4427-SERAIC, IRSET (Institut de Recherche en Santé Environnement Travail), Université Rennes 1, Rennes, France.
Systemic infections, such as toxoplasmosis, acquired during pregnancy can lead to placental infection and have profound effects on the mother-to-child relationship and the success of pregnancy. Placental permeability to Toxoplasma gondii is a main parameter that determines parasite transmission to the foetus, and the use of antibiotics to decrease placental parasite load and prevent congenital toxoplasmosis has been suggested for decades. Although parasitological examination of the placenta at birth is commonly used to diagnose neonatal congenital toxoplasmosis, this approach can be controversial. Here we argue in favour of placental examination for both diagnostic and epidemiological purposes.
Copyright © 2011 Elsevier Ltd. All rights reserved.
PMID:22079164[PubMed - as supplied by publisher]