Infect Immun. 2011 Nov 21. [Epub ahead of print]
An Inside Job: Hacking Into JAK/STAT Signaling Cascades by the Intracellular Protozoan Toxoplasma gondii.
Denkers EY, Bzik DJ, Fox BA, Butcher BA.
SourceDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca NY.
The intracellular protozoan Toxoplasma gondii is well known for its skill at invading and living within host cells. New discoveries are now also revealing the astounding ability of the parasite to inject effector proteins into the cytoplasm to seize control of the host cell. This Review summarizes recent advances in our understanding of one such secretory protein called ROP16. This molecule is released from rhoptries into the host cell during invasion. The ROP16 molecule acts as a kinase, directly activating both STAT3 and STAT6 signaling pathways. In macrophages, an important and preferential target cell of parasite infection, the injection of ROP16 has multiple consequences, including down-regulation of proinflammatory cytokine signaling and macrophage deviation to an alternatively activated phenotype.
PMID:22104110[PubMed - as supplied by publisher]