Cell Host Microbe. 2010 Dec 16;8(6):463-4.
Parasites paralyze cellular host defense system to promote virulence
Feng CG, Sher A.
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
To promote their survival, intracellular pathogens must confront microbicidal activities induced by interferons. In this issue of Cell Host & Microbe, Fentress et al. show that Toxoplasma gondii evades intracellular killing by deploying a virulence determinant, ROP18, which acts by directly phosphorylating and disabling an IFN-γ-inducible immunity-related GTPase involved in pathogen clearance.
Copyright © 2010 Elsevier Inc. All rights reserved.
PMID: 21147459 [PubMed - in process]