Wednesday, July 21, 2010

Association of host mitochondria with the parasitophorous vacuole during Toxoplasma infection is not dependent on rhoptry proteins ROP2/8

Int J Parasitol. 2010 Jul 14. [Epub ahead of print]

Association of host mitochondria with the parasitophorous vacuole during Toxoplasma infection is not dependent on rhoptry proteins ROP2/8

Pernas L, Boothroyd JC.

Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305-5124, USA.

Abstract
Previous work has proposed rhoptry protein 2 (ROP2) as the physical link that tethers host mitochondria to the parasitophorous vacuole membrane (PVM) surrounding the intracellular parasite, Toxoplasma gondii. A recent analysis of the ROP2 structure, however, raised questions about this model. To determine whether ROP2 is necessary, we created a parasite line that lacks the entire ROP2 locus consisting of the three closely related genes, ROP2a, ROP2b and ROP8. We show that this knockout mutant retains the ability to recruit host mitochondria in a manner that is indistinguishable from the parental strain, re-opening the question of which molecules mediate this association. Copyright © 2010. Published by Elsevier Ltd.

PMID: 20637758 [PubMed - as supplied by publisher]

3 comments:

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