Wednesday, June 30, 2010

Immunogenetics of Toxoplama gondii informs vaccine design

Trends Parasitol. 2010 Jun 25. [Epub ahead of print]

Immunogenetics of Toxoplama gondii informs vaccine design

Henriquez FL, Woods S, Cong H, McLeod R, Roberts CW.

School of Science, University of the West of Scotland, Paisley, PA1 2BE, UK.

A series of studies over 20 years mapped resistance to toxoplasmic encephalitis in mice to major histocompatibility complex class I (MHC I) and ultimately, more precisely the Ld region. This is consistent with contemporary functional studies that demonstrated a protective role for CD8(+) T cells. Recent studies have demonstrated that the Ld gene product presents a number of immunodominant Toxoplasma gondii-derived peptides in the murine models, providing a paradigm for vaccine design. The almost complete sequencing of the genomes of the predominant strains of T. gondii in conjunction with the development of predictive binding algorithms for MHC I peptides in humans now offers a new opportunity for vaccine development against this medically important pathogen. Copyright © 2010. Published by Elsevier Ltd.

PMID: 20580611 [PubMed - as supplied by publisher]

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