Wednesday, May 19, 2010

A decade of epigenetic research in Toxoplasma gondii

Mol Biochem Parasitol. 2010 May 11. [Epub ahead of print]

A decade of epigenetic research in Toxoplasma gondii

Dixon SE, Stilger KL, Elias EV, Naguleswaran A, Sullivan WJ Jr.

Department of Pharmacology & Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, 46202.

In the past ten years, the field of parasitology has witnessed an explosion of studies investigating gene regulation. In this review, we will describe recent advances largely stemming from the study of Toxoplasma gondii, a significant opportunistic pathogen and useful model for other apicomplexan protozoa. Surprising findings have emerged, including the discovery of a wealth of epigenetic machinery in these primitive eukaryotes, unusual histone variants, and a battery of plant-like transcription factors. We will elaborate on how these unusual features impact parasite physiology and potential therapeutics as we summarize some of the key discoveries from the last decade. We will close by proposing a few questions to address in the next ten years. Copyright © 2010. Published by Elsevier B.V.

PMID: 20470832 [PubMed - as supplied by publisher]

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