Wednesday, September 02, 2009

Reporter genes facilitating discovery of drugs targeting protozoan parasites

Trends Parasitol. 2009 Aug 29. [Epub ahead of print]

Reporter genes facilitating discovery of drugs targeting protozoan parasites

Dube A, Gupta R, Singh N.

Division of Parasitology, Central Drug Research Institute, Lucknow 226 001, India.

Transfection of protozoan parasites, such as Plasmodium, Leishmania, Trypanosoma and Toxoplasma, with various reporter gene constructs, has revolutionized studies to understand the biology of the host-parasite interactions at the cellular level. It has provided impetus to the development of rapid and reliable drug screens both for established drugs and for new molecules against different parasites and other pathogens. Furthermore, reporter genes have proved to be an excellent and promising tool for studying disease progression. Here, we review the recent advances made by using reporter genes for in vitro and in vivo drug screening, high-throughput screening, whole-animal non-invasive imaging for parasites and for the study of several aspects of host-parasite interactions.

PMID: 19720564 [PubMed - as supplied by publisher]

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