Tuesday, July 14, 2009

Postdoctoral Position

Postdoctoral Position in Molecular and Cellular Parasitology

A postdoctoral position is available immediately in the laboratory of Anthony Sinai PhD. at the University of Kentucky. The laboratory’s interests are in the area of the Cell Biology of the Host-Pathogen interaction using Toxoplasma gondii as a model system. We are particularly interested in the modulation of host functions surrounding the apoptotic cascade and the NFkappaB pathway by the parasite. In addition following collaborative proteomic we have identified a large number of proteins in the vacuolar membrane surrounding the intracellular parasites many of which are fertile targets for investigation. Among targets we a re interested in are glycoproteins likely involved in tissue cyst formation. Finally, in a new direction for the lab we are beginning to investigate the relationship between host energy metabolism and parasite growth and differentiation. The approaches used in the laboratory include state of the art cell biological (fluorescence, confocal and electron microscopy, live cell imaging, flow cytometry, subcellular fractionation), biochemical (protein biology and purification, proteomics, assay development) and molecular biological (genetic screens, molecular cloning, quantitative RT-PCR, bioinformatics). The laboratory is currently supported by an RO1 grant from the NIH with additional support pending. The successful candidate should have a background in molecular and/or cell biology and an interest in microbial pathogenesis. Salary and benefits will be commiserate with experience. The Department of Microbiology, Immunology and Molecular Genetics, offers a highly interactive environment with an emphasis on training. The University is located in Lexington, Kentucky and offers an excellent quality of life. The University of Kentucky is committed to Equal Employment Opportunity and Affirmative Action.

Please submit a curriculum vitae, a 1-2 page outline of research interests and professional goals and the names of 3 professional references. Information should be submitted electronically (as pdf files) to Anthony Sinai PhD. E-mail : sinai@uky.edu. Web site: http://www.mc.uky.edu/microbiology/sinai.asp

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