Exp Parasitol. 2009 Feb 12. [Epub ahead of print]
Toxoplasma gondii: congenital transmission in a hamster model
Freyre A, Fialho CG, Bigatti LE, Araujo FA, Falcón JD, Mendez J, González M.
Laboratorio de Toxoplasmosis, Departamento de Parasitologi a, Facultad de Veterinaria, Montevideo, Uruguay.
The objective of the research was to test the hamster for a model of transmission of congenital toxoplasmosis. A non invasive method for the diagnosis of pregnancy in hamsters was designed, with a specificity and a sensitivity of 70.2 and 94.7%, respectively (n=168). Of 32 females with a chronic toxoplasma infection, 3 transmitted Toxoplasma congenitally during their first pregnancy, but not during the subsequent pregnancy. Congenital transmission rates of infections initiated during pregnancy with 2 stages of 2 strains of Toxoplasma were in the range of 33 to 100% of the 76 females inoculated . Only 1 of 17 females transmitted the parasite exclusively via milk. It was concluded that the hamster is a promising species for a model of transmission of congenital toxoplasmosis.
PMID: 19217907 [PubMed - as supplied by publisher]