Eur J Clin Microbiol Infect Dis. 2008 Oct 15. [Epub ahead of print]
Toxoplasma gondii antibody profile in HIV-infected pregnant women and the risk of congenital toxoplasmosis
Lago EG, Conrado GS, Piccoli CS, Carvalho RL, Bender AL.
Department of Pediatrics, Pontifícia Universidade Católica do Rio Grande do Sul-School of Medicine, Av. Ipiranga 6690, Porto Alegre, 90610, Rio Grande do Sul, Brazil, firstname.lastname@example.org.
The purpose of this study was to investigate the antibodies to Toxoplasma gondii in human immunodeficiency virus (HIV)-infected pregnant women and to determine the association between serological profile and the risk of congenital toxoplasmosis. The study, conducted in a public maternity ward from May 2002 to April 2005, included all HIV-infected women who delivered live infants during the 36 months, and, as a control group, all HIV-negative women that delivered live infants in the first 12 months of the study. Antibodies to T. gondii were detected in 1,624 of 2,421 HIV-negative women (67%; 95% confidence interval [CI] 65-69%) and in 121 of 168 HIV-infected patients (72%; 95% CI 65-79%). A total of 547 HIV-negative and 103 HIV-infected patients were tested at delivery and had positive T. gondii-specific IgG. In HIV-negative women, the median of the specific IgG concentration was 79 (interquartile range 38-160), and in HIV-infected patients, it was 283 (interquartile range 94-704) (P < 0.001). In the group of co-infected women, the only infant with congenital toxoplasmosis was born to a mother with acute toxoplasmosis infection acquired during pregnancy who did not have a high specific IgG concentration or a positive result for specific IgM. We concluded that high T. gondii-specific IgG values were much more frequent among HIV-infected pregnant women, but it did not translate into an increased risk of maternal-fetal transmission of toxoplasmosis.
PMID: 18855029 [PubMed - as supplied by publisher]