Antimicrob Agents Chemother. 2008 Sep 29. [Epub ahead of print]
Inhibition of Toxoplasma gondii by Indirubin and Tryptanthrin Analogs
Krivogorsky B, Grundt P, Yolken R, Jones-Brando L.
Stanley Laboratory, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore Md; Department of Chemistry and Biochemistry, University of Minnesota Duluth, Duluth Minn.
New drugs are needed for treatment of Toxoplasma gondii infections. We tested derivatives of principles found in Isatis indigotica for in vitro efficacy against T. gondii. Indirubin-3'-oxime analogs showed modest micromolar activity, while tryptanthrin derivatives displayed ID50s in low nanomolar range. Tryptanthrins have potential as anti-Toxoplasma therapeutics.
PMID: 18824607 [PubMed - as supplied by publisher]