Toxoplasma gondii gene expression is under the control of regulatory pathways acting through chromatin structure

Parasite. 2008 Sep;15(3):206-10

Toxoplasma gondii gene expression is under the control of regulatory pathways acting through chromatin structure

Bougdour A, Sautel CF, Cannella D, Braun L, Hakimi MA

Laboratoire Adaptation et Pathogénie des Micro-organismes, Université Joseph Fourier Grenoble 1, BP 170, F-38042 Grenoble cedex 9, France.

The activity state of a gene is determined by a complex regulatory network of co-acting factors affecting the structure of the chromatin into which the gene is embedded. While significant changes of the transcriptome occur during cell differentiation in apicomplexan parasites, basic mechanisms controlling gene expression are still unknown. Recent studies support and expand the concept of the chromatin environment being key factor for the control of transcriptional activity in these lower eukaryotes organisms. Here, we review recent advances in the field of epigenetic gene regulation in Toxoplasma gondii, the model apicomplexan.

PMID: 18814682 [PubMed - in process]