Int Immunopharmacol. 2008 Oct;8(10):1316-9. Epub 2008 Jan 18
Role of lipoxin in the modulation of immune response during infection
Machado FS, Aliberti J.
Division of Molecular Immunology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Pro-inflammatory mediators such as IL-12, IFN-gamma and TNF are essential in controlling parasite growth during Toxoplasma gondii infection. However, it is clear that the exacerbate production of these cytokines results in the host tissue damage. Investigation into the immune response modulation during infectious disease, has revealed that lipoxin (LXA), an anti-inflammatory eicosanoids, plays an important role in regulation of immune response to different pathogens, including T. gondii and Mycobacterium tuberculosis. Here, we review the pro-resolution pathways triggered by LXA that are responsible for control of pro-inflammatory response during chronic disease.
PMID: 18687293 [PubMed - in process]