Pediatr Infect Dis J. 2008 May;27(5):469-474
CONGENITAL TOXOPLASMOSIS: SPECIFIC IgG SUBCLASSES IN MOTHER/NEWBORN PAIRS
Cañedo-Solares I, Galván-Ramírez MD, Luna-Pastén H, Rodríguez Pérez LR, Ortiz-Alegría LB, Rico-Torres CP, Vela-Amieva M, Pérez-Andrade M, Figueroa-Damián R, Correa D.
From the *Inmunología Experimental, Subdirección de Medicina Experimental, Instituto Nacional de Pediatría, Secretaría de Salud, México DF; †Centro Universitario de Ciencias de la Salud de la Universidad de Guadalajara; and ‡Instituto Nacional de Perinatología, Secretaría de Salud, México DF, México.
Anti-Toxoplasma gondii antibodies of all IgG subclasses were studied in mother/newborn pairs. IgG1 in the mothers and IgG3 in the newborns were related to offspring clinical problems; IgG2 and IgG3 in the babies were markers of vertical transmission, and IgG4 in mothers or children were associated to clinical problems. IgG subclasses may be markers of congenital infection or clinical outcome.
PMID: 18520342 [PubMed - as supplied by publisher]
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