Traffic. 2008 Feb 11 [Epub ahead of print]
Secretion of proteins into host cells by Apicomplexan parasites
Ravindran S, Boothroyd JC
Department of Microbiology and Immunology Stanford University School of Medicine Stanford, CA 94305-5124, USA.
The phylum Apicomplexa consists of a diverse group of obligate, intracellular parasites. The distinct evolutionary pressures on these protozoans as they have adapted to their respective niches has resulted in a variety of methods that they use to interact with and modify their hosts. One of these is the secretion and trafficking of parasite proteins into the host cell. We review this process for Theileria, Toxoplasma, and Plasmodium. We also present what is known about the mechanisms by which parasite proteins are exported into the host cell, as well as information on their known and putative functions once they have reached their final destination.
PMID: 18266908 [PubMed - as supplied by publisher]