Infect Immun. 2007 Feb 5; [Epub ahead of print]
The SAG1 Toxoplasma Surface Protein is Not Required for Acute Ocular Toxoplasmosis in Mice
Charles E, Callegan MC, Blader IJ.
Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104.
The SAG1 Toxoplasma surface protein stimulates acute ileitis. To test if SAG1 is also important in the eye, wild-type or SAG1 knockout parasites were intravitreally injected into mice. No differences in retinal damage or parasite growth were observed indicating that, unlike the intestine, factors besides SAG1 are important for retinal damage.
PMID: 17283084 [PubMed - as supplied by publisher]