Thursday, January 18, 2007

Cytokine regulation of immunopathology in toxoplasmosis

Immunol Cell Biol. 2007 Jan 16; [Epub ahead of print]

Cytokine regulation of immunopathology in toxoplasmosis.

Gaddi PJ, Yap GS.

1Department of Molecular Microbiology and Immunology, Brown University, Providence, RI, USA.

Toxoplasma gondii infection is an important cause of central nervous system and ocular disease, both in immunocompromised and in certain immunocompetent populations. Although parasite-mediated host cell lysis is probably the principal cause of tissue destruction in immunodeficiency states, hypersensitivity and inflammatory responses may underlie severe disease in otherwise immuno-sufficient individuals. In this review, we have critically evaluated the body of experimental evidence indicating a role of CD4 T cells in systemic and local immunopathology associated with T. gondii infection. We also discuss the pathogenic roles of cytokines produced by T helper (Th) 1 and Th17 cells and the protective and homeostatic roles of interleukin (IL)-10, transforming growth factor-beta and IL-27 in modulating hypersensitivity responses induced by T. gondii. Immunology and Cell Biology advance online publication, 16 January 2007; doi:10.1038/sj.icb.7100038.

PMID: 17228318 [PubMed - as supplied by publisher]

No comments: